With the four-game suspension of Tom Brady over, the Patriots started Brady against the Cleveland Browns.
After forcing the Browns to a quick three-and-out, the Patriots raced 80 yards in just 8 plays with Blount scoring on a 1-yard touchdown run to take the early 7–0 lead. However, the Browns countered with a 75-yard drive to score on an 11-yard touchdown pass from rookie Cody Kessler to Andrew Hawkins. The Patriots answered right back though, driving 75 yards in 8 plays, with Brady throwing a 7-yard touchdown pass to Bennett, retaking the lead 14-7. On the second play of the Browns' next drive, Kessler fumbled the snap, but kicked the ball out of the end zone for a safety, extending the Patriots lead to 16–7. Charlie Whitehurst took over for an injured Kessler on the next drive, but the Browns punted. After Edelman returned the free kick 9 yards to the New England 36, the Patriots marched 64 yards, aided by a 43-yard completion to Hogan, and scored on Brady's 5-yard touchdown pass to Bennett, increasing their lead to 23–7 early in the second quarter. After forcing the Browns to punt, the Patriots drove 72 yards, all the way to the Browns 1-yard line, but Blount couldn't get in on 3rd or 4th down, and the Patriots turned the ball over on downs. Three possessions later, the Patriots reached the Browns 32, but Gostkowski missed a 50-yard field goal attempt. The Browns ran out the rest of the clock, and the Patriots held their 23-7 lead going into halftime.
The Patriots didn't miss a beat in the second half, taking the opening drive 75 yards and increasing their lead on 37-yard catch-and-run by Bennett, Brady and Bennett's third touchdown connection of the game. The Browns drove to the Patriots 39 on their ensuing possession , but Whitehurst was intercepted by Patrick Chung, who returned it 4 yards to the Patriots' 34. Three possessions later, the Whitehurst drove the Browns 80 yards in just 7 plays, capping it off with his 17-yard touchdown pass to Connor Hamlett, trimming the deficit to 30-13, but the two-point conversion attempt failed, keeping the deficit to three scores. The Patriots answered right back, marching to the Browns 13 and Gostkowski extended the lead to 33-13 on his 31-yard field goal. Terrelle Pryor took for Whitehurst midway through the their next possession, but the Browns turned the ball over on downs. Both teams ran out the rest of the clock, and the Patriots went to 4-1.
Tom Brady also obtained his 8th 400+ passing yard game of his career.