Coming off of their Week 9 bye, the Patriots hosted the Seattle Seahawks on Sunday Night Football in a rematch of Super Bowl XLIX.
The Patriots marched 75 yards in 9 plays on their first drive of the game, with LeGarrette Blount scoring on a 1-yard touchdown run. Placekicker Stephen Gostkowski's kick went out of bounds, giving Seattle the ball at their own 40. The Seahawks reached the Patriots 8-yard line, but the Patriots red zone defense held them to a 26-yard field goal by placekicker Steven Hauschka and the score was 7–3. After a Patriots three-and-out, the Seahawks drove 66 yards in 10 plays, reaching the Patriots 13, but once again the Patriots kept them out of the end zone, and Hauschka kicked a 31-yard field goal, trimming the deficit to 7–6. After another Patriots three-and-out, the Seahawks 65 yards in 10 plays, this time reaching the end zone on quarterback Russell Wilson's 6-yard touchdown pass to wide receiver Doug Baldwin, but the PAT was blocked, keeping the score 12–7. On the second play of the Patriots next drive, tight end Rob Gronkowski seemed to fumble after being hit hard by safety Earl Thomas, but replay overturned it. Two plays later, cornerback DeShawn Shead intercepted quarterback Tom Brady at the Seattle 22 and returned it 2 yards to the Seahawks 24. The Patriots forced Seattle to punt, then marched 81 yards in 11 plays, scoring on Blount's 1-yard touchdown run with 1:05 remaining in the first half. However, 1:05 was too much time for Seattle as they raced 75 yards in under a minute, with Wilson finding Baldwin wide open in the end zone for an 18-yard touchdown, giving Seattle a 19–14 lead at halftime.
After a Seahawks three-and-out, the Patriots had their way with Seattle on 10 play, 91-yard drive, scoring on Blount's 13-yard touchdown run,re-taking the lead, 21-19. Seattle countered with a long drive of their own, advancing 52 yards in 9 plays, taking a 22–21 lead on Hauschka's 41-yard field goal. The Patriots countered Seattle's field goal with one of their own, marching 63 yards in 10 plays, reaching the Seattle, but the Seahawks clamped down, and drove the Patriots back to the 12 and forced them to settle for Gostkowski's 30-yard field goal, retaking the lead 24–22. Seattle countered as well, racing 58 yards in 8 plays, reaching the New England 5, but the Patriots red zone defense once more kept them out of the end zone, and Hauschka was good from 23 yards away, his fourth, retaking the lead for Seattle, 25–24. Kickoff returner Cyrus Jones fumbled the kick return, but safety Nate Ebner recovered, but two plays later, after a 5-yard gain, safety Kam Chancellor forced wide receiver Julian Edelman to fumble, with Richard Sherman returning the ball 14-yards to the Patriots 48. Eight plays later, Wilson capped off the 48-yard drive with his touchdown pass to Baldwin, with a failed two point conversion, keeping the Patriots in the game 31–24. Facing a 3rd-and-10 at their own 46, Brady hit Edelman on a 30-yard bomb to the Seahawks 24. After a 4-yard loss by Blount, Brady hit Gronkowski on a 26-yard bomb to the Seahawks 2. Very close to the end zone, Brady gained 1-yard on the sneak attempt. But on the very next play, Blount was stuffed for no gain, bringing up 3rd-and-Goal at the 1. Brady tried to sneak again, but fumbled and recovered at the Seahawks 2. On 4th-and-Goal Gronkowski couldn't handle a pass from Brady and the Patriots turned it over on downs. The Seahawks ran out the final seconds and won the game. In the final drive of the Patriots, they were just stopped short at the 1 yard line by the Seahawks. This caused the Patriots to lose the game.
The Pats dropped to a record of 7–2, still first in the AFC as of week 10 in the 2016 NFL season. The Seahawks improved to a record of 6–2–1.