After forcing a three-and-out, the Jets marched 41 yards to the Patriots 33, finishing the drive with a 51-yard field goal by Nick Folk. On the Patriots third possession of the game, Gronk came off to the sideline injured. He would go to the locker room and wouldn't play another game that season. Later in the first quarter, the Jets marched 79 yards, converting a 3rd-and-9, with Ryan Fitzpatrick finding Brandon Marshall for a 1-yard touchdown pass on the first play of the second quarter, increasing the lead to 10-0. The Patriots responded on their next drive, reaching the Jets 8, but after a 2-yard sack and an incompletion, Gostkowski kicked a 28-yard fiel goal, trimming the deficit to 10-3. On the second play of the Jets ensuing possession, Fitzpatrick connected with Robby Anderson for a 25-yard gain, but Anderson was stripped by Malcolm Butler, who recovered at midfield. The Patriots drove 50 yards, only facing one third-down, and scored on a 4-yard touchdown catch by Malcolm Mitchell. The Jets drove to the Patriots 36 on their next drive, but Folk missed a 54-yard field goal attempt. With great field position at their own 46, the Patriots drove 33 yards to the Jets 21, but Gostkowski missed a 39-yarder, sending the game to halftime tied 10-10.
After a Jets three-and-out, the Patriots marched all the way to the Jets 11, but the Jets clamped down and forced a 29-yard field goal by Gostkowski, giving the Patriots their first lead, 13-10. After swapping punts, the Jets covered 73 yards, not facing a single third down, regaining the lead with Fitzpatrick throwing a 22-yard pass to Quincy Enunwa with 10:17 remaining in the fourth quarter. Down 17-13, the Patriots advanced to the Jets 22, but decided to kick a 40-yard field goal, trimming the deficit to 17-16. The Jets reached their own 27, but an intentional grounding penalty pushed them back, and they punted two plays later. A holding penalty on McCourty negated Amendola's 15-yard return which would've set the Patriots up at their own 42. Starting at their own 17, Brady led a clutch, 9 play, 83-yard drive. Facing a 4th-and-4 at the Jets 37, Brady completed three consecutive passes: a 4-yard completion to White, a 25-yard completion to Hogan, and then an 8-yard touchdown pass to Mitchell, with a missed two-point conversion, giving the Patriots a 22-17 lead with just 1:56 remaining. After a five-yard completion to Jalin Marshall, Fitzpatrick was strip-sacked by Long with Trey Flowers recovering at the Jets 34. Two third-down conversions clinched the win for the Patriots.
With the win, the Patriots improved to 9–2 and clinched their 16th consecutive winning season. This was also the Patriots' 500th franchise win, as well as Tom Brady's 200th career win, tying him with Peyton Manning and surpassing Brett Favre, who had 199 wins. In addition to this, Tom Brady also surpassed the 60,000-yard career passing mark.